Studimi i ri zbulon mekanizmin q\u00eb lejon q\u00eb myku e rrezikshme t\u00eb q\u00ebndroj\u00eb n\u00eb l\u00ebkur\u00ebn e njeriut p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb – Zbulimi hap rrug\u00ebn p\u00ebr m\u00ebnyra t\u00eb reja p\u00ebr ta trajtuar at\u00eb.<\/p>\n\n\n\n
Mund t\u00eb jet\u00eb n\u00eb heshtje n\u00eb l\u00ebkur\u00eb pa shkaktuar probleme. Atje, mund t\u00eb mbijetoj\u00eb p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb, pa u v\u00ebn\u00eb re. Dhe kur gjen mund\u00ebsin\u00eb t\u00eb hyj\u00eb m\u00eb thell\u00eb n\u00eb trupin e nj\u00eb pacienti t\u00eb preksh\u00ebm, mund t\u00eb shkaktoj\u00eb nj\u00eb infeksion serioz, madje k\u00ebrc\u00ebnues p\u00ebr jet\u00ebn.<\/p>\n\n\n\n
Candida auris<\/strong>, nj\u00eb myk rezistente ndaj shum\u00eb ila\u00e7eve q\u00eb \u00ebsht\u00eb b\u00ebr\u00eb nj\u00eb sfid\u00eb e ve\u00e7ant\u00eb p\u00ebr spitalet n\u00eb t\u00eb gjith\u00eb bot\u00ebn, duket se ka nj\u00eb “arm\u00eb” tjet\u00ebr: Fshehet thell\u00eb n\u00eb folikulat e flok\u00ebve dhe arrin ta kthej\u00eb mbrojtjen imunitare t\u00eb l\u00ebkur\u00ebs n\u00eb drejtimin e gabuar.<\/p>\n\n\n\n Mekanizmi mbres\u00ebl\u00ebn\u00ebs u zbulua nga shkenc\u00ebtar\u00ebt e Universitetit t\u00eb Kalifornis\u00eb, San Francisko (UCSF), n\u00eb nj\u00eb studim t\u00eb ri t\u00eb botuar n\u00eb Science. Zbulimi mund t\u00eb shpjegoj\u00eb nj\u00eb nga karakteristikat q\u00eb e b\u00ebjn\u00eb Candida auris<\/strong> nj\u00eb kund\u00ebrshtar kaq t\u00eb v\u00ebshtir\u00eb: Aft\u00ebsin\u00eb e saj p\u00ebr t\u00eb q\u00ebndruar n\u00eb l\u00ebkur\u00eb p\u00ebr periudha t\u00eb gjata kohore dhe, p\u00ebr k\u00ebt\u00eb arsye, t\u00eb gjej\u00eb mund\u00ebsi p\u00ebr transmetim n\u00eb mjedisin spitalor.<\/p>\n\n\n\n Myku q\u00eb vazhdon aty ku t\u00eb tjerat zhduken<\/strong>.<\/p>\n\n\n\n “Candida auris<\/strong> kolonizon l\u00ebkur\u00ebn shum\u00eb m\u00eb mir\u00eb se shumica e myqeve t\u00eb tjera, gj\u00eb q\u00eb i jep asaj aft\u00ebsin\u00eb p\u00ebr t\u00eb pushtuar kur sistemi imunitar dob\u00ebsohet”, shpjegon Dr. Dean Merrill, dermatolog, profesor n\u00eb UCSF dhe autori i par\u00eb i studimit.<\/p>\n\n\n\n Dhe k\u00ebtu q\u00ebndron nj\u00eb nga sfidat m\u00eb t\u00eb r\u00ebnd\u00ebsishme p\u00ebr mjek\u00ebt: Si\u00e7 thekson studiuesi, aktualisht nuk ka nj\u00eb m\u00ebnyr\u00eb efektive p\u00ebr t\u00eb hequr plot\u00ebsisht Candida auris<\/strong> nga l\u00ebkura.<\/p>\n\n\n\n Si e “ngat\u00ebrron” sistemin imunitar.<\/strong><\/p>\n\n\n\n Candida auris<\/strong> b\u00ebn di\u00e7ka t\u00eb ndryshme. Ajo ndryshon murin e saj t\u00eb jasht\u00ebm qelizor p\u00ebr t\u00eb ekspozuar m\u00eb shum\u00eb nj\u00eb substanc\u00eb t\u00eb quajtur kitin\u00eb. Prania e saj shkakton qelizat imune t\u00eb prodhojn\u00eb interferon-gama (IFN-\u03b3), nj\u00eb sinjal imunitar m\u00eb i lidhur me mbrojtjen kund\u00ebr viruseve. Me fjal\u00eb t\u00eb tjera, myku duket se po e \u00e7on sistemin imunitar n\u00eb nj\u00eb p\u00ebrgjigje q\u00eb nuk \u00ebsht\u00eb m\u00eb efektive n\u00eb neutralizimin e saj.<\/p>\n\n\n\n Dhe rezultati \u00ebsht\u00eb edhe m\u00eb interesant: Interferon-gama shtyp mbrojtjen natyrore antifungale t\u00eb l\u00ebkur\u00ebs, duke p\u00ebrfshir\u00eb IL-17.<\/p>\n\n\n\n N\u00eb t\u00eb nj\u00ebjt\u00ebn koh\u00eb, rinovimi normal i qelizave n\u00eb folikulat e flok\u00ebve ngadal\u00ebsohet. Kjo b\u00ebn q\u00eb qelizat m\u00eb t\u00eb vjetra dhe t\u00eb d\u00ebmtuara t\u00eb grumbullohen, duke krijuar nj\u00eb mjedis ve\u00e7an\u00ebrisht t\u00eb favorsh\u00ebm n\u00eb t\u00eb cilin Candida auris<\/strong> mund t\u00eb mbijetoj\u00eb. Nj\u00eb lloj “foleje”, si\u00e7 e p\u00ebrshkruajn\u00eb studiuesit.<\/p>\n\n\n\n Pse \u00ebsht\u00eb problem p\u00ebr spitalet<\/strong>.<\/p>\n\n\n\n Problemi ndodh kryesisht kur myqet l\u00ebvizin n\u00eb inde m\u00eb t\u00eb thella ose n\u00eb qarkullimin e gjakut, ve\u00e7an\u00ebrisht tek pacient\u00ebt me probleme serioze sh\u00ebndet\u00ebsore dhe sistem imunitar t\u00eb dob\u00ebsuar.<\/p>\n\n\n\n Aft\u00ebsia e saj p\u00ebr t\u00eb kolonizuar l\u00ebkur\u00ebn vazhdimisht, e kombinuar me rezistenc\u00ebn e saj ndaj shum\u00eb ila\u00e7eve antifungale, e ka b\u00ebr\u00eb at\u00eb nj\u00eb kund\u00ebrshtar ve\u00e7an\u00ebrisht t\u00eb v\u00ebshtir\u00eb p\u00ebr institucionet e kujdesit sh\u00ebndet\u00ebsor.<\/p>\n\n\n\n “P\u00ebr shumic\u00ebn e njer\u00ebzve, Candida auris<\/strong> q\u00ebndron n\u00eb l\u00ebkur\u00eb dhe nuk shkakton probleme”, shpjegon Profesori i Imunologjis\u00eb n\u00eb UCSF, Ari Molofsky. “Vet\u00ebm kur arrin indet m\u00eb t\u00eb thella tek pacient\u00ebt e preksh\u00ebm nga ana mjek\u00ebsore, b\u00ebhet e rrezikshme.”<\/p>\n\n\n\n Nj\u00eb “pik\u00eb e dob\u00ebt” e re p\u00ebr mykun?<\/strong><\/p>\n\n\n\n Nj\u00eb strategji e mundshme do t\u00eb ishte zhvillimi i terapive q\u00eb do t\u00eb ridrejtonin p\u00ebrgjigjen imune nga interferoni-gama n\u00eb IL-17, duke rivendosur k\u00ebshtu mekanizmin normal antifungal t\u00eb l\u00ebkur\u00ebs.<\/p>\n\n\n\n Nj\u00eb qasje e dyt\u00eb mund t\u00eb synonte kitin\u00ebn q\u00eb myku p\u00ebrdor p\u00ebr t\u00eb shkaktuar k\u00ebt\u00eb p\u00ebrgjigje imune t\u00eb pazakont\u00eb.<\/p>\n\n\n\n P\u00ebr momentin, k\u00ebto jan\u00eb drejtime k\u00ebrkimore, jo trajtime t\u00eb disponueshme. Por zbulimi i ndihmon shkenc\u00ebtar\u00ebt t\u00eb kuptojn\u00eb m\u00eb mir\u00eb se si nj\u00eb mikroorganiz\u00ebm mund t\u00eb jetoj\u00eb i qet\u00eb mbi ne, duke shmangur neutralizimin nga sistemi imunitar derisa t\u00eb paraqitet mund\u00ebsia p\u00ebr t’u b\u00ebr\u00eb i rreziksh\u00ebm.<\/p>\n\n\n\n Dhe n\u00eb rastin e Candida auris<\/strong>, t\u00eb kuptuarit se si arrin t\u00eb \u201cfshihet\u201d mund t\u00eb jet\u00eb hapi i par\u00eb n\u00eb gjetjen e nj\u00eb m\u00ebnyre p\u00ebr ta zhdukur at\u00eb.<\/p>\n","protected":false},"excerpt":{"rendered":" Studimi i ri zbulon mekanizmin q\u00eb lejon q\u00eb myku e rrezikshme t\u00eb q\u00ebndroj\u00eb n\u00eb l\u00ebkur\u00ebn e njeriut p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb – Zbulimi hap rrug\u00ebn p\u00ebr m\u00ebnyra t\u00eb reja p\u00ebr ta trajtuar at\u00eb. Mund t\u00eb jet\u00eb n\u00eb heshtje n\u00eb l\u00ebkur\u00eb pa shkaktuar probleme. Atje, mund t\u00eb mbijetoj\u00eb p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb, pa u […]<\/p>\n","protected":false},"author":1,"featured_media":6056,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[566,583],"tags":[],"class_list":["post-7846","post","type-post","status-publish","format-standard","has-post-thumbnail","category-shendeti","category-shendetsore"],"yoast_head":"\n
P\u00ebr t\u00eb kuptuar se \u00e7far\u00eb e b\u00ebn Candida auris<\/strong> kaq efektive n\u00eb kolonizimin e l\u00ebkur\u00ebs, studiuesit e krahasuan at\u00eb me Candida albicans, nj\u00eb myk shum\u00eb m\u00eb e zakonshme. Dallimi ishte i habitsh\u00ebm. N\u00eb eksperimentet me minj, Candida albicans u zhduk brenda pak dit\u00ebsh. Candida auris<\/strong>, n\u00eb t\u00eb kund\u00ebrt, mbeti n\u00eb l\u00ebkur\u00eb, duke gjetur streh\u00eb brenda folikulave t\u00eb flok\u00ebve.<\/p>\n\n\n\n
Shkenc\u00ebtar\u00ebt zbuluan se t\u00eb dy myqet provokojn\u00eb nj\u00eb p\u00ebrgjigje krejt\u00ebsisht t\u00eb ndryshme t\u00eb sistemit imunitar. Candida albicans aktivizon nj\u00eb sinjal imunitar t\u00eb quajtur interleukin\u00eb-17 (IL-17). Kjo p\u00ebrgjigje rrit mbrojtjen natyrore antifungale t\u00eb trupit dhe rinovimin e sip\u00ebrfaqes s\u00eb l\u00ebkur\u00ebs, duke e ndihmuar trupin t\u00eb heq\u00eb qafe mykun.<\/p>\n\n\n\n
Candida auris<\/strong> u identifikua p\u00ebr her\u00eb t\u00eb par\u00eb n\u00eb Japoni n\u00eb vitin 2009 dhe q\u00eb at\u00ebher\u00eb \u00ebsht\u00eb shfaqur n\u00eb spitale dhe institucione t\u00eb tjera t\u00eb kujdesit sh\u00ebndet\u00ebsor n\u00eb shum\u00eb vende. Prania e saj n\u00eb l\u00ebkur\u00eb nuk do t\u00eb thot\u00eb domosdoshm\u00ebrisht se dikush \u00ebsht\u00eb i s\u00ebmur\u00eb. Tek shum\u00eb njer\u00ebz, mund t\u00eb jet\u00eb i pranish\u00ebm pa shkaktuar simptoma.<\/p>\n\n\n\n
Zbulimi i mekanizmit me t\u00eb cilin Candida auris<\/strong> siguron pranin\u00eb e saj n\u00eb l\u00ebkur\u00eb mund t’u ofroj\u00eb shkenc\u00ebtar\u00ebve objektiva t\u00eb rinj terapeutik\u00eb.<\/p>\n\n\n\n